QIAxcel Advanced Application Guide 10/2016 5 One major factor determining the success of an assay and its reproducibility is the quality of the sample itself. The QIAxcel Advanced addresses this challenge by performing fast and reliable quality control of your nucleic acid samples with only little input material. It measure the concentration of your samples, analyzes their size distribution as well as their integrity so you can assess their potential to achieve quality results. This enables you to standardize the quality of your samples early on and thus make well-informed decision prior to processing them through your workflow. gDNA extraction from tissues, cells or organisms is a crucial first step for all subsequent DNA analyses. Evaluation of RNA (either for total RNA and/or messenger RNA) quality and quantity is critical for many molecular biology techniques as well as microarray-based research experiments. Accurate quantification of NGS library fragments in a high-throughput automated fashion is becoming significantly important for many research laboratories. Content • Quality control of genomic DNA using the QIAxcel system • Quality control of total RNA and cRNA for microarray analysis • Identifying rare mutations in Diamond-Blackfan anemia using target enrichment and next-generation sequencing