Application Guide - QIAxcel Advanced

QIAxcel Advanced Application Guide 10/2016 39 Biomedical research primarily involves screening amplicons for mutations, detecting deletion/insertions in DNA samples and identifying gene rearrangements with the aim of diagnosing a disease, identifying biomarkers for personalized medicine or for HLA profiling. A better understanding of human genetics and reliable screening of genotypes is critical in biomedical research. In order to apply genetic analyses to large groups of samples or population screening, automation of capillary electrophoresis on QIAxcel facilitates rapid processing of a large number of samples in a timely fashion. QIAxcel instrument offers more robust results with high reproducibility using less sample input material. Content • Mutation screening of c-kit and EGFR using the QIAxcel system prior to Pyrosequencing • Rapid Analysis of Deletions/Duplications with MLPA Using the QIAxcel Advanced System • Rapid and accurate detection of Y chromosome microdeletions • Reliable and fast detection of B-cell clonality in lymphoproliferations • Safe and rapid HLA typing using the QIAxcel system

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