Unraveling the human microbiome
If it’s on or under your skin, it is worth analyzing! Studying how the gut microbiome affects someone’s mood or metabolic disorders? Are you investigating how resident microbes are affected by cancer and vice versa ? Linking the human microbiome to a research question for insightful results requires a reliable workflow from sample preparation and nucleic acid isolation to sequencing and bioinformatics.
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What is the human microbiome?
Microorganisms (such as bacteria, archaea, fungi, viruses and eukaryotes) that live in communities on or in the human body are collectively called the human microbiome. These microbes, which live in a plethora of tissues, regions or fluids of the human body, can be beneficial or harmful depending on their composition.
What role does the human gut microbiome play in health and disease?
The gut microbiome plays a pivotal role in human health and disease and is essential for human development, immunity and nutrition. Often referred to as the microbiota-gut-brain-axis, the underlying molecular mechanisms that comprise the link between the gut microbiome and its effect on our brain and behaviour are slowly being revealed. The disturbance of the gut microbiome homeostasis has been associated with various pathological conditions, both systemic (obesity, diabetes, cancer and atopy) and gut-related (irritable bowel syndrome IBS, inflammatory bowel disease IBD).