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Next-Generation Sequencing

Multiply your biomarker profiling power with multimodal sequencing

Why choose QIAseq Multimodal technology?

Recent advances in NGS and bioinformatics have empowered researchers to simultaneously sequence DNA and RNA from biological samples. However, current approaches require two separate workflows for DNA and RNA library preps, which call for higher input materials, longer turnaround times and increased costs .

One sample, flexible options—to accelerate your multiomic studies

With QIAseq Multimodal technology, you can take a whole-omics approach (whole genome and whole transcriptome) or a targeted approach by amplicon- or hybrid capture-based enrichment, to examine DNA and RNA analytes. The automation-friendly workflows enable simultaneous profiling of DNA and RNA biomarkers from a single sample to accelerate your multiomic studies. Moreover, QIAseq Multimodal chemistries facilitate reliable and sensitive detection of variants from a diverse array of sample types and require as little as 10 ng of input.  

  
Unlock DNA and RNA biomarker insights simultaneously
Explore how QIAseq Multimodal technology can save you valuable resources and time – discuss your project needs with us.
Applying multimodal sequencing technology to profile solid tumors
Dr. Barnaby Clark, Laboratory Lead for Precision Medicine at Kings College Hospital NHS Foundation Trust, discusses how QIAseq multimodal sequencing technology reduces his overall turnaround times for processing solid tumor samples due to simultaneous DNA and RNA library prep and automation.
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Explore performance data and more in our downloadable resources!
Target regions of interest with custom panels

Incorporate the benefits of QIAseq Multimodal technology and design your own panels. With our custom designs, you can target exonic regions of genes, hotspots or SNPs, intronic and promoter regions, known gene fusions based on characterized breakpoints and even discover novel fusions.

QIAseq Multimodal
Have a question about custom design?
Our specialists are ready to help you.

Comprehensive genomic profiling (CGP) is dramatically changing our understanding of various cancers, revealing an unprecedented level of detail. Multimodal sequencing can accelerate this rapidly evolving field of research.

Top 3 reasons to adopt a multimodal approach for CGP:

  1. Save time and resources: Consolidate separate workflows into a single-day, sample to sequencing workflow.
  2. Conserve precious samples: Simultaneously profile multiple DNA and RNA biomarkers, TMB and MSI from a single, low-input sample.
  3. Get deeper insights: Achieve a holistic view of various DNA and RNA biomarkers efficiently.
QIAseq Multimodal
Unlock insights into multiple cancers with just 10 ng total nucleic acid input

The QIAseq Pan-cancer Multimodal Panel enables simultaneous enrichment and profiling of 605 relevant DNA variant and RNA fusion biomarkers found across multiple cancers, as well as assessment of tumor mutational burden (TMB) and microsatellite instability (MSI), from a single sample input of 10 ng.

Ask our experts about comprehensive genomic profiling
Explore how QIAseq Multimodal technology can transfrom your cancer research.
What can you profile with the QIAseq Pan-cancer Multimodal Panel?

Explore the QIAseq Pan-cancer Multimodal Panel

Cover 523 DNA gene targets, 56 RNA fusion targets and 26 MSI loci.
Simultaneously purify gDNA and total RNA from FFPE tissues

For multiomic studies that examine genomic and transcriptomic interactions, purifying DNA and RNA from the same sample is crucial. Separate DNA and RNA isolation procedures contribute to variabilities and require more input material, which is problematic when specimens are scarce.

Achieve comprehensive DNA and RNA analysis of the same FFPE sample by purifying both analytes simultaneously using the AllPrep DNA/RNA FFPE Kit. Overcome the effects of formaldehyde degradation and achieve high-quality DNA and RNA.

EZ1&2 DNA FFPE Kit
Automate and accelerate your library prep
How can automating your NGS library prep benefit your lab?
All photos taken prior to COVID-19