COVID-19

Surveillance solutions

Sample to Insight COVID-19 wastewater testing

There's growing evidence that successful detection of SARS-CoV-2 RNA in wastewater or natural sewage is a powerful surveillance tool to prevent a surge in COVID-19 infections, and specifically of new variants that are gaining ground in certain communities. QIAGEN supports wastewater-based epidemiology efforts with research tools spanning nucleic acid extraction, amplification and detection, overcoming some of the common challenges with the analytical protocols along the workflow.

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PCR

Corona virus, COVID-19, virus with antibodies

Understanding SARS-CoV-2 epidemiology from every angle

SARS-CoV-2 detection is made easier thanks to the QIAprep&amp Viral RNA UM Kit. The kit can be combined with a unique qPCR assay design to detect the highly mutable SARS-CoV-2 virus with reliability and specificity. You can also use it in conjunction with a menu of genotyping assays to determine relevant mutations in your SARS-CoV-2 samples. In addition, effective multiplexing helps distinguish between co-circulating viruses (SARS-CoV-2, influenza A/B, and RSV A/B) during the respiratory virus season. Discover a robust, simple and cost-effective method to meet your present and future epidemiological research goals.

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NGS

NGS for epidemiological variant surveillance

Develop a comprehensive picture of circulating variants by ramping up SARS-CoV-2 genomic surveillance with a dramatically faster, high-throughput NGS solution. New QIAseq DIRECT SARS-CoV-2 Kits provide superior sequence uniformity and depth of coverage of the SARS-CoV-2 genome. Maximize efficiency, reduce hands-on time with a 4-hour, automatable workflow and cut down plasticware use by 50%. With QIAseq DIRECT SARS-CoV-2 Kits, you can multiplex up to 768 samples to improve scalability and efficiency.

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Genomic services

Whole genomic sequencing services

QIAGEN Genomic Services provides a comprehensive Sample-to-Insight SARS-CoV-2 Whole Genome Sequencing Services to support your research. Whether you’re studying strain evolution or performing phylogeographic or metagenomic analyses, Genomic Services is the right partner for providing impactful insights and helping accelerate your COVID-19 research. This service uses technology especially designed for SARS-CoV-2 research.

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Pyrosequencing

Pyrosequencing for COVID-19 genotyping

The prevalence of variants must be rapidly detected and reported to keep pace with the mutating SARS-CoV-2 virus. NGS is the current gold standard for genotyping of SARS-CoV-2; however, it is not feasible to genotype samples in real-time on a population-wide scale. RT-qPCR assays could provide an alternative approach that supplements NGS surveillance activities with its ability to genotype all SARS-CoV-2 cases on the day that it is detected. However, it is time-consuming to develop new assays for each emerging mutation, leading to potential delays in surveillance. The Pyrosequencing method presents a cost-effective solution and makes it easier to design new assays for emerging variants.

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Bioinformatics

Bioinformatics analysis of SARS-CoV-2 with QIAGEN Digital Insights

To support the efforts of clinical microbiology and public health laboratories involved in SARS-CoV-2 sequencing, QIAGEN offers free temporary licenses to QIAGEN CLC Genomics and QIAGEN Ingenuity Pathway Analysis (IPA) bioinformatics software. In addition, until June 30, 2021 we are offering labs that purchase the QIAseq SARS-CoV-2 Primer Panel Kit (96) a 25% discount off any 1-year subscription to QIAGEN CLC Genomics bioinformatics software.

Additionally, our data scientists have expanded upon recent peer-reviewed research to generate relevant SARS-CoV-2 protein networks. This freely available Coronavirus Network Explorer helps you visualize how SARS-CoV-2 proteins interact with human host proteins to disable protective responses and pathways, and explore hypotheses around ways to fight coronavirus.

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Immune response

Maximize insights from SARS-CoV-2 T cell immune response

T cells are increasingly recognized for their role in SARS-CoV-2 infection and immunity, and the exploration of immune response markers during COVID-19 infection is becoming the next tool for researching potential improvements in patient management and vaccination guidance in the future.

The QuantiFERON SARS-CoV-2 RUO solution uses a combination of antigens specific to SARS-CoV-2 to stimulate lymphocytes in heparinized whole blood. Plasma from the stimulated samples can be used for detection of cytokines, including IFN-γ.

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Sample prep

Best in class sample prep

We have an extensive portfolio of RNA extraction kits for purification of high-quality RNA. You can be confident in your downstream results because our kits help deliver highly pure nucleic acid free of contaminants and inhibitors. Options are available in specific formats and throughputs, as well as for manual and automated processing.

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Additional resources

QIAGEN solutions

QIAstat-Dx
The next generation of syndromic insights
Harness the full potential of multiplex syndromic testing and confidently provide clinical insights to patients with the highest level of versatility.
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QIAGEN Digital Insights
Bioinformatics analysis of SARS-CoV-2 with QIAGEN Digital Insights
To support the efforts of labs sequencing the SARS-CoV-2 virus on the front lines of the COVID-19 pandemic, QIAGEN is offering free temporary licenses to researchers worldwide involved with COVID-19 research and response.
Free temporary license
QIAcube Connect
Redefining automated sample processing
Fully automate QIAGEN gold-standard spin-column purification procedures with the new QIAcube Connect instrument.
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EZ1 DSP Virus Kit
Contains all required reagents for automated purification
The EZ1 DSP Virus Kit is ideal for automated, simultaneous purification of viral nucleic acids and bacterial DNA from 1–6 or 1–14 human biological specimens.
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QIAamp Viral RNA Mini Kit
For isolation of viral RNA from cell-free body fluids
By binding viral RNA to the QIAamp silica membrane, the QIAamp Viral RNA Mini Kit simplifies purification of viral RNA from cell-free body fluids with fast spin-column or vacuum procedures. The procedure can be fully automated.
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EZ1 Advanced XL
For automated nucleic acid purification
With EZ1 Advanced XL you can fully automate your nucleic acid purification from a wide range of sample types relevant for molecular diagnostics.
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