Is the morphology after H&E staining comparable to formalin-fixed samples?

Yes. No major differences in morphology were observed in adjacent pieces from a tissue sample fixed either with neutral-buffered formalin or with the PAXgene Tissue System for a variety of human and animal tissue (Kap et al., PLoS ONE 6(11): e27704). Examples are provided in the Tissue Atlas.

However, PAXgene Tissue treated specimens have a tendency to be more eosinophilic. If an identical staining pattern to formalin-fixed samples is required, the incubation time in eosin should be reduced.