Is the surface tension of the crystallization supports of the EasyXtal 15-Well Tools similar to that of a siliconized cover slide?
We tested many plastics and chose one whose hydrophobic properties are close to those of siliconized cover slides. Nevertheless, the behavior of a drop may vary in some cases depending on the protein buffer and the crystallization condition. If you observe too much spreading, you can use DropGuard Crystallization Supports. These supports contain 6 cavities and have been designed to prevent drops from spreading when using conditions containing organics (e.g., MPD) or detergents.