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In this webinar, we will take a look at a large-scale SNP-based forensic identification panel for DNA analysis with massively parallel sequencing (MPS). The panel was specifically designed for the challenges of identifying missing persons; where DNA is frequently highly degraded, and relationship tests may involve reference samples from across several generations and in a deficient pedigree.
显示详细信息
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The FBI CODIS Core Loci Working Group have published the recommendation that the CODIS core loci should be expanded, and a combination of STR markers from the Combined DNA Index System (CODIS), the European Network of Forensic Science Institutes (ENFSI), and the European DNA Profiling Group (EDNAP) should be used to improve the accuaracy of forensic testing.
QIAGEN has developed new kits — Investigator 24plex Kits — that coamplify all 23 recommended markers. The kits use novel 6-dye technology to keep the amplicon length of markers short while avoiding overlapping of markers. Kits are available for purified DNA from casework and for reference samples.
This webinar will outline the benefits of the Investigator 24plex Kits and highlight the improved workflow, which saves unnecessary re-runs of a sample by use of an internal “Quality Sensor” control.
This unique Quality Sensor can distinguish:
Successful amplification
Degraded DNA
Inhibited DNA
No DNA
Failed PCR amplification
Join us to learn how to improve results and streamline your forensic STR analysis with the new Investigator 24plex Kits.
显示详细信息
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The core short tandem repeats (STRs) in worldwide use have served the forensic analyst very well for many years. Further, recent expansions of European Standard STR sets plus ongoing discussions to extend CODIS have brought powerful upgrades to the battery of core markers available. However, there are still scenarios when supplementary STRs could enhance the data necessary for interpreting complex forensic patterns: making safer inferences about relatedness across distant relationships in deficient pedigrees, and in the not too distant future, improving the specificity of familial searching or expanding the points of reference to better interpret mixed profiles.
The QIAGEN HDplex Kit contains 9 completely novel STRs in addition to ESS or CODIS D12S39, D18S51 and SE33 markers. On an average, these 9 novel STRs provide higher powers of discrimination than kits using the core loci alone.
This webinar will outline the completed studies on worldwide patterns of variability in the 12 novel HDplex STRs and their ability to enhance the power of paternity analyses when combined with existing markers.
It will also describe the upgraded pop.STR allele frequency browser which provides data for 23 core STRs plus a total of 28 supplementary STRs in 56 global populations.
Join us to learn more on:
Enhancing data necessary for interpreting complex forensic patterns with supplementary STRs
Making safer inferences about relatedness across distant relationships in deficient pedigrees
Improving the specificity of familial searching to better interpret mixed profiles
显示详细信息
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